Ecuador: Helicobacter pylori infections are highly prevalent, associated with gastric cancer

Posted on February 18, 2014 • Filed under: Ecuador, Latin America Health

In Ecuador, Helicobacter pylori infections are highly prevalent. A total of 42 H. pylori clinical isolates from 86 patients attending the outpatient clinic of the gastroenterology department of the university hospital of Guayaquil in Ecuador were characterized. Their susceptibility, and cagA and vacA status were determined. Resistance to metronidazole and clarithromycin was found in 80.9% and 9.5% of strains, respectively. Neither amoxicillin- nor tetracycline-resistant strains were found. The most prevalent genotype was the cagA(+), vacA s1b,m1 type. This genotype was associated with gastric cancer and peptic ulcer. Typing by random amplified polymorphic DNA showed no genetic relationship among the strains. The incidence of gastric cancer in Ecuador is high compared with other countries and is estimated at 29 cases per 100 000 inhabitants per year. A major risk factor for gastric cancer is
infection with Helicobacter pylori. Read Article
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