Ecuador: Neurological Manifestations from Zika, Chikungunya, Dengue virus

Zika Virus, Chikungunya Virus, and Dengue Virus in Cerebrospinal Fluid from Adults with Neurological Manifestations, Guayaquil, Ecuador

Citation: Acevedo N, Waggoner J, Rodriguez M, Rivera L, Landivar J, Pinsky B and Zambrano H (2017). Zika Virus, Chikungunya Virus, and Dengue Virus in Cerebrospinal Fluid from Adults with Neurological Manifestations, Guayaquil, Ecuador. Front. Microbiol. 8:42. doi: 10.3389/fmicb.2017.00042

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Zika virus (ZIKV), chikungunya virus (CHIKV), and dengue virus (DENV) have been associated with acute neurological manifestations. In the current study, we identified ZIKV, CHIKV and DENV in cerebrospinal fluid (CSF) samples from patients admitted with neurological symptoms and/or concern for acute arboviral infections. Viral RNA from one or more virus was detected in 12/16 patients. Six patients were diagnosed with meningitis or encephalitis, three with Guillain-Barré Syndrome, and one with CNS vasculitis. Two additional patients had a systemic febrile illness including headache that prompted testing of CSF. Two patients, who were diagnosed with encephalitis and meningoencephalitis, died during their hospitalizations. These cases demonstrate the breadth and significance of neurological manifestations associated with ZIKV, CHIKV and DENV infections. Read Article

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Copyright: © 2017 Acevedo, Waggoner, Rodriguez, Rivera, Landivar, Pinsky and Zambrano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.